ADP-ribosylation of RNA and DNA: from in vitro characterization to in vivo function

ADP-ribosylation of RNA and DNA: from in vitro characterization to in vivo function

The efficiency of DNA, RNA and proteins is altered dynamically in response to physiological and pathological cues, partly achieved by their modification. Whereas the modification of proteins with ADP-ribose has been successfully studied, nucleic acids have been solely simply these days acknowledged as substrates for ADP-ribosylation by mammalian enzymes. RNA and DNA could also be […]