![Novel amino substituted tetracyclic imidazo[4,5-b]pyridine derivatives: Design, synthesis, antiproliferative activity and DNA/RNA binding study](http://www.gehealthcarecamdengroup.com/wp-content/uploads/2021/04/IMG-20201217-WA0100.jpg)
A novel collection of tetracyclic imidazo[4,5-b]pyridine derivatives was designed and synthesized as potential antiproliferative brokers. Their antiproliferative exercise in opposition to human most cancers cells was influenced by the introduction of chosen amino facet chains on the completely different positions on the tetracyclic skeleton and significantly, by the place of N atom within the pyridine nuclei. Thus, the vast majority of compounds confirmed improved exercise compared to commonplace drug etoposide. A number of compounds confirmed pronounced cytostatic impact within the submicromolar vary, particularly on HCT116 and MCF-7 most cancers cells. The obtained outcomes have confirmed the numerous impression of the place of N nitrogen within the pyridine ring on the enhancement of antiproliferative exercise, particularly for derivatives bearing amino facet chains on place 2.
Thus, regioisomers 6, 7 and 9 confirmed noticeable enhancement of exercise compared to their counterparts 10, 11 and 13 with IC50 values in a nanomolar vary of focus (0.3-0.9 μM). Interactions with DNA (together with G-quadruplex construction) and RNA have been influenced by the place of amino facet chains on the tetracyclic core of imidazo[4,5-b]pyridine derivatives and the ligand cost. Average to excessive binding affinities (logKs = 5-7) obtained for chosen imidazo[4,5-b]pyridine derivatives counsel that DNA/RNA are potential cell targets. DNA and RNA have been measured with many methods however typically with comparatively lengthy evaluation instances.
On this examine, we make the most of fast-scan cyclic voltammetry (FSCV) for the subsecond codetection of adenine, guanine, and cytosine, first as free nucleosides, after which inside customized synthesized oligos, plasmid DNA, and RNA from the nematode Caenorhabditis elegans. Earlier research have proven the detection of adenosine and guanosine with FSCV with excessive spatiotemporal decision, whereas we have now prolonged the assay to incorporate cytidine and adenine, guanine, and cytosine in RNA and single- and double-stranded DNA (ssDNA and dSDNA). We discover that FSCV testing has the next sensitivity and yields larger peak oxidative currents when detecting shorter oligonucleotides and ssDNA samples at equal nucleobase concentrations.
That is in keeping with an electrostatic repulsion from negatively charged oxide teams on the floor of the carbon fiber microelectrode (CFME), the damaging holding potential, and the negatively charged phosphate spine. Furthermore, versus dsDNA, ssDNA nucleobases aren’t hydrogen-bonded to 1 one other and thus are free to adsorb onto the floor of the carbon electrode. We additionally reveal that the simultaneous dedication of nucleobases will not be masked even in biologically complicated serum samples. That is the primary report demonstrating that FSCV, when used with CFMEs, is ready to codetect nucleobases when polymerized into DNA or RNA and will doubtlessly pave the way in which for future makes use of in scientific, diagnostic, or analysis purposes.
DNA restore pathway activation options in follicular and papillary thyroid tumors, interrogated utilizing 95 experimental RNA sequencing profiles
DNA restore can forestall mutations and most cancers growth, however it might additionally restore broken tumor cells after chemo and radiation remedy. We carried out RNA sequencing on 95 human pathological thyroid biosamples together with 17 follicular adenomas, 23 follicular cancers, Three medullar cancers, 51 papillary cancers and 1 poorly differentiated most cancers. The gene expression profiles are annotated right here with the scientific and histological diagnoses and, for papillary cancers, with BRAF gene V600E mutation standing.
DNA restore molecular pathway evaluation confirmed strongly upregulated pathway activation ranges for many of the differential pathways within the papillary most cancers and reasonably upregulated sample within the follicular most cancers, when in comparison with the follicular adenomas. This was noticed for the BRCA1, ATM, p53, excision restore, and mismatch restore pathways. This discovering was validated utilizing unbiased thyroid tumor expression dataset PRJEB11591. We additionally analyzed gene expression patterns linked with the radioiodine resistant thyroid tumors (n = 13) and recognized 871 differential genes that in line with Gene Ontology evaluation fashioned two useful teams: (i) response to topologically incorrect protein and (ii) aldo-keto reductase (NADP) exercise.
We additionally discovered RNA sequencing reads for 2 hybrid transcripts: one in-frame fusion for well-known NCOA4-RET translocation, and one other frameshift fusion of ALK oncogene with a brand new companion ARHGAP12. The latter may in all probability assist elevated expression of truncated ALK downstream from 4th exon out of 28. Each fusions have been present in papillary thyroid cancers of follicular histologic subtype with node metastases, certainly one of them (NCOA4-RET) for the radioactive iodine resistant tumor. The variations in DNA restore activation patterns could assist to enhance remedy of various thyroid most cancers varieties underneath investigation and the info communicated could serve for locating further markers of radioiodine resistance.
![Novel amino substituted tetracyclic imidazo[4,5-b]pyridine derivatives: Design, synthesis, antiproliferative activity and DNA/RNA binding study](http://www.gehealthcarecamdengroup.com/wp-content/uploads/2021/04/IMG-20201217-WA0100-484x1024.jpg)
An engineered CRISPR-Cas12a variant and DNA–RNA hybrid guides allow strong and fast COVID-19 testing
Intensive testing is important to interrupt the transmission of SARS-CoV-2, which causes the continued COVID-19 pandemic. Right here, we current a CRISPR-based diagnostic assay that’s strong to viral genome mutations and temperature, produces outcomes quick, could be utilized immediately on nasopharyngeal (NP) specimens with out RNA purification, and incorporates a human inside management throughout the identical response. Particularly, we present that using an engineered AsCas12a enzyme permits detection of wildtype and mutated SARS-CoV-2 and permits us to carry out the detection step with loop-mediated isothermal amplification (LAMP) at 60-65 °C.
 Total RNA from Mouse Normal Tissue: Brain |
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| R1334035-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Mouse Normal Tissue: Colon |
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| R1334090-50 | Biochain | 50 ug | EUR 214 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Mouse Normal Tissue: Heart |
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| R1334122-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Mouse Normal Tissue: Kidney |
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| R1334142-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Mouse Normal Tissue: Liver |
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| R1334149-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Mouse Normal Tissue: Lung |
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| R1334152-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Mouse Normal Tissue: Pancreas |
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| R1334188-50 | Biochain | 50 ug | EUR 341 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Mouse Normal Tissue: Placenta |
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| R1334200-50 | Biochain | 50 ug | EUR 214 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Mouse Normal Tissue: Rectum |
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| R1334206-50 | Biochain | 50 ug | EUR 214 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Mouse Normal Tissue: Spleen |
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| R1334246-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Mouse Normal Tissue: Stomach |
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| R1334248-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Mouse Normal Tissue: Testis |
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| R1334260-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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) Tissue Total RNA Mini Kit (50prep) |
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| FATRK-001 | Favorgen | 50 preps | EUR 165 |
) Tissue Total RNA Mini Kit (100prep) |
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| FATRK-001-1 | Favorgen | 100 preps | EUR 216 |
) Tissue Total RNA Mini Kit (300prep) |
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| FATRK-001-2 | Favorgen | 300 preps | EUR 404 |
) Tissue Total RNA Maxi Kit (10prep) |
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| FATRK-003 | Favorgen | 10 preps | EUR 201 |
) Tissue Total RNA Maxi Kit (24prep) |
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| FATRK-003-1 | Favorgen | 24 preps | EUR 317 |
 Total RNA from Mouse Normal Tissue: Whole Eye |
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| R1334108-50 | Biochain | 50 ug | EUR 296 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Mouse Normal Tissue: Skeletal Muscle |
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| R1334171-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Mouse Normal Tissue: Small Intestine |
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| R1334226-50 | Biochain | 50 ug | EUR 214 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 I: Major Organ) Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) I: Major Organ |
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| T8234431 | Biochain | 5 slides | EUR 261 |
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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
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 II: Major Organ) Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) II: Major Organ |
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| T8234432 | Biochain | 5 slides | EUR 261 |
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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
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 III: Major Organ) Paraffin Tissue Section Panel - Human Adult Normal Tissue, Multi-tissue (8) III: Major Organ |
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| T8234433 | Biochain | 5 slides | EUR 261 |
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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
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 Total RNA from Human Tumor Tissue: Adrenal |
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| R1235004-10 | Biochain | 10 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Bladder |
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| R1235010-10 | Biochain | 10 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Bone |
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| R1235023-10 | Biochain | 10 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Breast |
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| R1235086-50 | Biochain | 50 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Colon |
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| R1235090-50 | Biochain | 50 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Esophagus |
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| R1235106-50 | Biochain | 50 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Kidney |
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| R1235142-50 | Biochain | 50 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Liver |
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| R1235149-50 | Biochain | 50 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Lung |
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| R1235152-50 | Biochain | 50 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Nose |
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| R1235178-10 | Biochain | 10 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Ovary |
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| R1235183-10 | Biochain | 10 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Parotid |
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| R1235190-10 | Biochain | 10 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Rectum |
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| R1235206-50 | Biochain | 50 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Melanoma |
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| R1235218A-10 | Biochain | 10 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Stomach |
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| R1235248-50 | Biochain | 50 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Synoviosarcoma |
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| R1235257-10 | Biochain | 10 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Thymus |
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| R1235264-10 | Biochain | 10 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Thyroid |
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| R1235265-50 | Biochain | 50 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Tonsil |
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| R1235268-10 | Biochain | 10 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Tumor Tissue: Uterus |
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| R1235274-50 | Biochain | 50 ug | EUR 351 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Adipose |
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| R1434003-50 | Biochain | 50 ug | EUR 214 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Bladder |
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| R1434010-50 | Biochain | 50 ug | EUR 303 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Brain |
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| R1434035-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Colon |
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| R1434090-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Heart |
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| R1434122-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Kidney |
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| R1434142-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Liver |
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| R1434149-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Lung |
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| R1434152-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Ovary |
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| R1434183-50 | Biochain | 50 ug | EUR 296 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Pancreas |
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| R1434188-50 | Biochain | 50 ug | EUR 296 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Placenta |
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| R1434200-50 | Biochain | 50 ug | EUR 214 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Rectum |
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| R1434206-50 | Biochain | 50 ug | EUR 214 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Spleen |
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| R1434246-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Stomach |
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| R1434248-50 | Biochain | 50 ug | EUR 214 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Testis |
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| R1434260-50 | Biochain | 50 ug | EUR 152 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Rat Normal Tissue: Thymus |
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| R1434264-50 | Biochain | 50 ug | EUR 214 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Plant Normal Tissue: Arabidopsis |
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| R1634310 | Biochain | 100 ug | EUR 558 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Plant Normal Tissue: Corn |
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| R1634330 | Biochain | 100 ug | EUR 558 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Plant Normal Tissue: Orange |
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| R1634340 | Biochain | 100 ug | EUR 558 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Plant Normal Tissue: Potato |
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| R1634350 | Biochain | 100 ug | EUR 558 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Plant Normal Tissue: Rice |
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| R1634360 | Biochain | 100 ug | EUR 558 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Plant Normal Tissue: Wheat |
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| R1634390 | Biochain | 100 ug | EUR 558 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 FastPure Cell/Tissue Total RNA Isolation Kit |
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| RC101 | Vazyme | 50 rxn | EUR 229 |
 Frozen Tissue Section Panel - Mouse Whole Brain Segmentation Panel |
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| T6334035 | Biochain | 5 slides | EUR 931 |
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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
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 Paraffin Tissue Section Panel - Mouse Whole Brain Segmentation Panel |
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| T8334035 | Biochain | 5 slides | EUR 556 |
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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
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 Total RNA from Human Adult Normal Tissue: Adipose |
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| R1234003-10 | Biochain | 10 ug | EUR 194 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Adrenal |
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| R1234004-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Appendix |
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| R1234006-10 | Biochain | 10 ug | EUR 194 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Bladder |
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| R1234010-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Brain |
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| R1234035-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Breast |
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| R1234086-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Cecum |
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| R1234089-10 | Biochain | 10 ug | EUR 194 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Colon |
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| R1234090-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Epididymis |
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| R1234105-10 | Biochain | 10 ug | EUR 266 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Esophagus |
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| R1234106-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Gallbladder |
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| R1234118-10 | Biochain | 10 ug | EUR 194 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Heart |
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| R1234122-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Kidney |
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| R1234142-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Liver |
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| R1234149-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Lung |
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| R1234152-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Trachea |
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| R1234160-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Ovary |
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| R1234183-10 | Biochain | 10 ug | EUR 280 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Pancreas |
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| R1234188-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Parotid |
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| R1234190-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Penis |
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| R1234194-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Placenta |
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| R1234200-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Prostate |
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| R1234201-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Rectum |
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| R1234206-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Skin |
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| R1234218-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Spleen |
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| R1234246-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Stomach |
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| R1234248-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Testis |
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| R1234260-50 | Biochain | 50 ug | EUR 178 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Throat |
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| R1234263-10 | Biochain | 10 ug | EUR 194 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Total RNA from Human Adult Normal Tissue: Thymus |
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| R1234264-50 | Biochain | 50 ug | EUR 966 |
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Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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We additionally discover that using hybrid DNA-RNA guides will increase the speed of response, enabling our take a look at to be accomplished inside 30 minutes. Using scientific samples from 72 sufferers with COVID-19 an infection and 57 wholesome people, we reveal that our take a look at reveals a specificity and constructive predictive worth of 100% with a sensitivity of 50 and 1000 copies per response (or 2 and 40 copies per microliter) for purified RNA samples and unpurified NP specimens respectively.